ChemicalBook CAS DataBase List 2-PHENYLBENZYL BROMIDE

2-PHENYLBENZYL BROMIDE synthesis

13synthesis methods

Product Name:2-PHENYLBENZYL BROMIDE
CAS Number:19853-09-9
Molecular formula:C13H11Br
Molecular Weight:247.13

98-80-6 Synthesis

98-80-6
734 suppliers
$5.00/5g

3433-80-5 Synthesis

3433-80-5
314 suppliers
$10.00/1g

19853-09-9
59 suppliers
$22.00/250mg

Yield:19853-09-9 79%

Reaction Conditions:

with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂;potassium carbonate in 1,4-dioxane at 100; for 3 h;

Steps:

1.1 1) Preparation of 2-(bromomethyl)-1,1'-biphenyl:
2-Bromomethylbromobenzene (7.53 mmol, 1 eq.), phenylboronic acid (9.04 mmol, 1.2 eq.) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride DichloromethaneThe complex (0.45 mmol, 0.06 equivalent) was placed in a 50 ml round bottom flask, and 10 ml of dioxane and 10 ml of a 2 mol/L K2CO3 solution were added, respectively, and refluxed at 100 ° C for 3 h. The reaction was quenched by the addition of a saturated NaCl solution, cooled to room temperature and extracted three times with ethyl acetate.Dry with anhydrous Na2SO4 and collect the product by silica gel column chromatography.The yield was 79%.

References:

Shenzhen University;Wu Haiqiang;Liu Zhigang;He Zhendan;Yu Xi;Li Yue;Zou Yongdong;Zheng Yizhi;Liu Lizhong;Wu Xuli CN108912051, 2018, A Location in patent:Paragraph 0034; 0036; 0037; 0038

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643-58-3 Synthesis