2-OXAZOLECARBOXYLIC ACID synthesis
- Product Name:2-OXAZOLECARBOXYLIC ACID
- CAS Number:672948-03-7
- Molecular formula:C4H3NO3
- Molecular Weight:113.07
288-42-6
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124-38-9
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672948-03-7
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$104.00/100mg
Yield: 96%
Reaction Conditions:
Stage #1:carbon dioxide with AuOH(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene);potassium hydroxide in tetrahydrofuran at 20; under 1125.11 Torr; for 0.25 h;
Stage #2:oxazol in tetrahydrofuran at 20; under 1125.11 Torr; for 12 h;
Stage #3: with hydrogenchloride in tetrahydrofuran;waterregioselective reaction;
References:
Boogaerts, Ine I. F.;Nolan, Steven P. [Journal of the American Chemical Society,2010,vol. 132,# 26,p. 8858 - 8859] Location in patent:supporting information; experimental part