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98829-12-0

2-O-octadecylascorbic acid synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 40 percent / potassium carbonate / tetrahydrofuran; dimethylformamide / 4 h / Ambient temperature
2: 68 percent / potassium carbonate / tetrahydrofuran; dimethylsulfoxide / 3 h / 50 °C
3: aq. HCl / tetrahydrofuran; methanol / 6 h / Ambient temperature
4: hydrogen / 5percent Pd/C / ethanol / 18 h

References:

Kato;Terao;Shimamoto;Hirata [Journal of Medicinal Chemistry,1988,vol. 31,# 4,p. 793 - 798]

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