ChemicalBook CAS DataBase List 2'-O-Methyluridine

2'-O-Methyluridine synthesis

12synthesis methods

Product Name:2'-O-Methyluridine
CAS Number:2140-76-3
Molecular formula:C10H14N2O6
Molecular Weight:258.23

2'-O-Methyluridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process. It can be synthesized from Uridine by condensation reaction.

Uridine, 2'-O-methyl-3-[(phenylmethoxy)methyl]-3'-O-(phenylmethyl)-

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2140-76-3
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Yield:2140-76-3 95%

Reaction Conditions:

with formic acid;palladium on activated charcoal;hydrogen in water;isopropyl alcohol; under 760.051 Torr; for 12 h;

Steps:

General procedure for BOM deprotections

General procedure: To a stirred solution of the BOM protected uridine derivative (1 equiv) in ⁱPrOH:H₂O (10:1) and HCO₂H (0.5%) was added 10% Pd-C (10%) under N₂. H₂ gas was introduced to the reaction mixture using a double-folded balloon. Upon completion, the reaction mixture was filtered through a Celite pad and washed with EtOAc (or MeOH). All volatiles were evaporated in vacuo. When the HCO₂H-amine salt was generated, the crude mixture was dissolved in CHCl₃ and washed with aq. NaHCO₃. The combined organic extracts were dried over Na₂SO₄ and evaporated in vacuo. Purification by silica gel chromatography afforded the desired compound.