ChemicalBook CAS DataBase List 2-Naphthaldehyde

2-Naphthaldehyde synthesis

14synthesis methods

Product Name:2-Naphthaldehyde
CAS Number:66-99-9
Molecular formula:C11H8O
Molecular Weight:156.18

939-26-4
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66-99-9
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Yield:66-99-9 94%

Reaction Conditions:

with hexamethylenetetramine;water;sodium dodecyl-sulfate;lanthanum(lll) triflate at 100; for 1.5 h;Green chemistry;Sommelet Aldehyde Synthesis;

Steps:

Synthesis of 3o; typical procedure
General procedure: Hexamethylenetetramine 1 (70.1 mg), SDS (3.4 mg) and lanthanum triflate (17.6 mg) were dissolved in water (0.5 mL). Then 1o (271 mg) was added to the flask. The mixture was refluxed for 4 h to complete the reaction, which was monitored by TLC. The reaction mixture was extracted with EtOAc three times and the combined organic phases were distilled under reduced pressure. The crude product was purifiedby column chromatography on silica gel using hexane: EtOAc (5 : 1) as eluent to give 3o, recrystallisation of which from EtOH gave white crystals, 147 mg (71%) (Table 3, entry 1).

References:

Xu, Wenhao;Su, Weike [Journal of Chemical Research,2014,vol. 38,# 12,art. no. A3,p. 710 - 714]

1592-38-7 Synthesis