ChemicalBook CAS DataBase List 2-MORPHOLINO-3-PYRIDINAMINE

2-MORPHOLINO-3-PYRIDINAMINE synthesis

4synthesis methods

Product Name:2-MORPHOLINO-3-PYRIDINAMINE
CAS Number:51627-47-5
Molecular formula:C9H13N3O
Molecular Weight:179.22

24255-27-4 Synthesis

24255-27-4
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$16.00/250mg

51627-47-5
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$32.00/250mg

Yield:51627-47-5 90.1%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; for 10 h;Solvent;

Steps:

6.B

4-(3-Nitropyridin-2-yl)morpholine (11.0 g, 52.6 mmol) was dissolved in methanol (100 mL)Add 10% palladium on carbon (5.6 g, 5.3 mmol),Hydrogen was introduced and reacted at room temperature for 10 h.After the reaction is completed, the solvent is distilled off under reduced pressure.The residue was dissolved in water (100 mL).Extracted with ethyl acetate (100 mL×3),The organic phase was collected and dried over anhydrous sodium sulfate.The solid was filtered off, and the solvent was evaporated under reduced pressure.The residue was passed through a silica gel column (mobile phase: PE: EA = 10:1).2-morpholinopyridine-3-amine gray solid 8.5 g was obtained in a yield of 90.1%.

References:

CN107840820,2018,A Location in patent:Paragraph 0018; 0028; 0038; 0048; 0058; 0065; 0067; 0068