Methyl carbamimidothioate synthesis
- Product Name:Methyl carbamimidothioate
- CAS Number:2986-19-8
- Molecular formula:C2H6N2S
- Molecular Weight:90.15
Yield:2986-19-8 89.01 g
Reaction Conditions:
in ethanol at 40;
Steps:
1
Mix 54.4g of methyl chloroacetate and 110ml of dry toluene, cool, and add 31.6g of methyl formate when the temperature drops to 0°C, and then add 28.2g of 97% when the internal temperature drops to -10°C-5°C Sodium methoxide, Reacted for 4h at 5°C, and then reacted for 3h at room temperature, and finally 28.15g yellow oil was obtained. It is the crude product of methyl α-chloroformyl acetate. Take 76g (1mol) of thiourea dissolved in 400ml of absolute ethanol, slowly add 141.90 (1mol) of methyl iodide dropwise, after the dropwise addition, control the temperature at about 40, react until the solution is clear and stop the reaction, cool and stand for crystallization ,filter, Obtained 89.01 g of white crystals, namely methyl isothiourea.
References:
Maidexin International Co., Ltd.;Zhao Haifeng CN112079794, 2020, A Location in patent:Paragraph 0089; 0097-0099
66356-40-9
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