2-METHYL-2-NITRO-1,3-PROPANEDIOL synthesis
- Product Name:2-METHYL-2-NITRO-1,3-PROPANEDIOL
- CAS Number:77-49-6
- Molecular formula:C4H9NO4
- Molecular Weight:135.12
Yield: 88.9%
Reaction Conditions:
with sodium carbonate in water; pH=9 at 25 - 50; for 0.5 h;
Steps:
1.1 (1) Synthesis of 2-methyl-2-nitro-1,3-propanediol
Under stirring, at a temperature of 25°C to 30°C, add 2.05 mol of 37% to 40% formaldehyde aqueous solution to the reaction bottle. When heated to 50°C, add Na2CO3 to adjust PH = 9, dropwise add 1.0 mol of nitroethane, dropwise Keep the temperature around 50 °C during the process, and then react at 50°C for 30min after the dropwise addition.Add 20% H2SO4 to adjust PH=7, distill off water under reduced pressure, cool to room temperature, filter with suction, and dry to obtain 120 g of 2-methyl-2-nitro-1,3-propanediol with a yield of 88.9%.
References:
Xi'an Modern Chemical Institute;Liu Yajing;Ji Yueping;Mo Hongchang;Pan Yongfei;Liu Weixiao;Chen Bin;Ma Ling;Zhang Lijie;Lu Tingting;Ding Feng;Gao Fulei;Li Lei;Wang Yinglei;Lu Xianming CN110972529, 2017, B Location in patent:Paragraph 0009; 0020-0026
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