ChemicalBook CAS DataBase List 2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID

2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID synthesis

8synthesis methods

Product Name:2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID
CAS Number:42206-47-3
Molecular formula:C10H11NO4
Molecular Weight:209.2

74002-19-0
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2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID

42206-47-3
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Yield:42206-47-3 100%

Reaction Conditions:

with hydrogenchloride in tetrahydrofuran;water; for 20 h;Heating / reflux;

Steps:

78.B

To a solution of 2-(4-nitro-phenyl)-isobutyramide (538 mg; 2.59 mmol), prepared as in 78(A), in THF (25 mL), was added 37% HCl (5 mL) and the resulting reaction was refluxed for 20 hours. Then, the solution was concentrated under vacuum and the residue was portioned between DCM and water. The organic layer was dried (Na₂SO₄), filtered and evaporate under vacuum to give the title compound as a white solid (512 mg; quantitative yield).LCMS (RT): 3.1 min (Method A); MS (ES+) gave m/z: 210.00 (MH+).

References:

WO2008/117175,2008,A2 Location in patent:Page/Page column 124