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ChemicalBook CAS DataBase List 2-Methyl-[1,1'-biphenyl]-3-carbaldehyde
89951-60-0

2-Methyl-[1,1'-biphenyl]-3-carbaldehyde synthesis

5synthesis methods
-

Yield:89951-60-0 96.9%

Reaction Conditions:

with manganese(IV) oxide in dichloromethane at 10 - 30; for 16 h;

Steps:

64 Synthesis of compound 64-d

Compound (2-methyl-[1,1'-biphenyl]-3-yl)methanol (1.98 g, 10.0 mmol) was dissolved inIn dichloromethane (100 mL), manganese dioxide (2.64 g, 30.0 mmol) was added to the solution.The reaction mixture was stirred at room temperature for 16 hours, filtered, and the filtrate was concentrated under reduced pressure.The residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate=10-5:1) to obtain colorless crystals64-d (1.9 g, yield: 96.9%).

References:

CN114230512,2022,A Location in patent:Paragraph 0959-0965

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