ChemicalBook CAS DataBase List 2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane synthesis

8synthesis methods

Product Name:2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS Number:1195-66-0
Molecular formula:C7H15BO3
Molecular Weight:158

76-09-5 Synthesis

76-09-5
384 suppliers
$8.19/250mg

121-43-7
356 suppliers
$13.00/25mL

2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1195-66-0
179 suppliers
$5.00/1g

Yield:1195-66-0 90%

Reaction Conditions:

for 6 h;Inert atmosphere;Reflux;

Steps:

Synthesis of 2-methoxy-4,4,5,5-tetramethyl[1,3,2]dioxaborolane
Synthesis of 2-methoxy-4,4,5,5-tetramethyl[1,3,2]dioxaborolane A flask equipped with a reflux condenser, stirrer, an inert gas inlet and a thermocouple set in heating mantle was charged with trimethyl borate and pinacol under positive pressure of nitrogen. The resulting mixture was heated at reflux for 6 hours. The mixture was cooled to ambient temperatures and transferred to a flask with a Vigreux column. The mixture was distilled at atmospheric pressure to afford 2-methoxy-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (bp 159° C.) in high yield (90%). ¹H NMR (400 MHz, CDCl₃): δ 3.41 (m, 3H), 1.11 (m, 12H). ¹¹B NMR (128.3 MHz, CDCl₃): δ 22.2. ¹³C NMR (100.6 MHz, CDCl₃): δ 82.7, 52.6, 24.6.

References:

Anderson Development Company US2012/289733, 2012, A1 Location in patent:Page/Page column 4

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