2-Isopropyl-6-propylphenol (Propofol Impurity O) synthesis
- Product Name:2-Isopropyl-6-propylphenol (Propofol Impurity O)
- CAS Number:74663-48-2
- Molecular formula:C12H18O
- Molecular Weight:178.27
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: 1 N aq. NaOH, benzyltri-n-butylammonium bromide / CH2Cl2 / 2 h / Ambient temperature
2: 1.5 h / 250 °C
3: H2 / 10percent Pd/C / ethanol / 0.25 h / 25 °C / 760 Torr
References:
James, Roger;Glen, John B. [Journal of Medicinal Chemistry,1980,vol. 23,# 12,p. 1350 - 1357]
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