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36044-41-4

2-Iodoazulene synthesis

10synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: ethanol; sodium / 72.15 h / 20 °C
2: lithium chloride / N,N-dimethyl-formamide; water / 21 h / Reflux
3: phosphorus tribromide / toluene / 2 h / 90 °C / Inert atmosphere
4: copper(l) iodide; potassium iodide / N,N-dimethyl-formamide / 16 h / Reflux

References:

Ohtsu, Keito;Hayami, Ryohei;Sagawa, Takuya;Tsukada, Satoru;Yamamoto, Kazuki;Gunji, Takahiro [Tetrahedron,2019,vol. 75,# 46,art. no. 130658]