ChemicalBook CAS DataBase List 2-Hydroxystyrene

2-Hydroxystyrene synthesis

13synthesis methods

Product Name:2-Hydroxystyrene
CAS Number:695-84-1
Molecular formula:C8H8O
Molecular Weight:120.15

63600-35-1
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$45.00/10mg

695-84-1
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$503.54/5MG

Yield: 96%

Reaction Conditions:

with ethanol;sodium hydroxide at 20; for 4 h;Inert atmosphere;

Steps:

1.1; 2.1 1) Preparation of Hydroxystyrene
0.275 mol of sodium hydroxide was put into a 500 ml round-bottom flask, 60 ml of anhydrous ethanol was added thereto to dissolve the sodium hydroxide, and then 0.065 mol of acetoxystyrene was added to the flask, and the resulting solution was stirred at room temperature in a nitrogen atmosphere for 4 hours.
Subsequently, 50 ml of distilled water and 30 ml of ethyl acetate were sequentially added to the resulting mixture to extract an organic layer, and the organic layer extraction process was repeated three times.
The extracted organic layer was dried with anhydrous magnesium sulfate and filtered to remove any remaining moisture.
Thereafter, the solvent was removed under reduced pressure to obtain 7.54 g (yield: 96%) of yellow solid hydroxystyrene.
¹H nuclear magnetic resonance (NMR) spectroscopic data of the purified hydroxystyrene is as follows:
¹H-NMR (500 MHz, CDCl₃) δ 7.31-7.29 (d, J=9.5, 1H), δ 6.80-6.78 (d, J=8.5, Ar-H, 2H), δ 6.68-6.62 (q, J=9.5, 1H), δ 5.62-5.58 (d, J=17.5, 1H), δ 5.13-5.11 (d, J=11, 1H), δ 4.75 (s, 1H).

References:

LG Chem, Ltd.;Kim, Min Soo;Choi, Won Mun;Joe, Dae June US2018/244819, 2018, A1 Location in patent:Paragraph 0029; 0030; 0033