ChemicalBook CAS DataBase List 2-HYDROXYACETOPHENONE

2-HYDROXYACETOPHENONE synthesis

13synthesis methods

Product Name:2-HYDROXYACETOPHENONE
CAS Number:582-24-1
Molecular formula:C8H8O2
Molecular Weight:136.15

50-00-0 Synthesis

50-00-0
864 suppliers
$10.00/25g

100-52-7 Synthesis

100-52-7
948 suppliers
$17.30/2g

582-24-1
246 suppliers
$8.00/5g

Yield:582-24-1 82%

Reaction Conditions:

with tetra-(n-butyl)ammonium iodide in acetonitrile;tert-butyl alcohol at 120; for 24 h;

Steps:

1 Example 1: Synthesis of -hydroxyacetophenone
To 25 mL pressure reaction tube was added acetonitrile 2mL,Benzaldehyde (31.8 mg, 0.3 mmol),Paraformaldehyde (27.0mg, 0.9 mmol),Tert-Butyl alcohol (83 mg, 2.0 eq.),Tetrabutylammonium iodide (22 mg, 0.2 eq.),The reaction was stirred magnetically in a 120 ° C oil bath for 24 hours.After the reaction was over, most of the solvent was distilled off under reduced pressure,The remaining mixture was separated by column chromatography using petroleum ether / ethyl acetate (10: 1)Get the desired product, a white solid,33.5 mg,Yield 82%

References:

Lishui College;Yan Guobing;Yu Jian;Wang Lianggui CN105061166, 2017, B Location in patent:Paragraph 0014; 0015; 0016

60-12-8 Synthesis