ChemicalBook CAS DataBase List 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide

2-Hydroxy-N-(4-hydroxyphenyl)-benzamide synthesis

4synthesis methods

Product Name:2-Hydroxy-N-(4-hydroxyphenyl)-benzamide
CAS Number:526-18-1
Molecular formula:C13H11NO3
Molecular Weight:229.23

123-30-8 Synthesis

123-30-8
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$10.00/5g

65-45-2 Synthesis

65-45-2
534 suppliers
$5.00/25g

526-18-1
143 suppliers
$5.00/25mg

Yield: 84%

Reaction Conditions:

with thionyl chloride in ethyl acetate at 170; for 6 h;Concentration;Temperature;

Steps:

3
General procedure: To the reaction vessel were added 0.07 mol of p-aminophenol, 0.076 mol of 2-hydroxy-benzamide and 80 ml of ethyl acetate, and the stirring rate was controlled at150rpm, slowly adding stannous chloride 0.031mol, the solution becomes darker color, add finished slowly heated to 170 , the reaction 6h, 2.1kPa vacuum distillationDistill part of ethyl acetate, lower the temperature of the solution to 38 , pour the reactant into 500ml mass fraction of 23% sodium bisulfite solution,Adding water 33% oxalic acid solution, adjusting the pH value to 4, precipitating the solid, separating the substance from the solution,Was recrystallized from 87% ethylenediamine solution to obtain 13.47 g of white solid N-p-hydroxyphenyl salicylamide in 84% yield.

References:

Chengdu Cardiff Technology Co., Ltd;Liao, Ruer CN105503633, 2016, A Location in patent:Paragraph 0006; 0014; 0015

123-30-8 Synthesis

123-30-8
614 suppliers
$10.00/5g

69-72-7 Synthesis