ChemicalBook CAS DataBase List 2-Hydroxy-5-bromopyridine

2-Hydroxy-5-bromopyridine synthesis

12synthesis methods

Product Name:2-Hydroxy-5-bromopyridine
CAS Number:13466-38-1
Molecular formula:C5H4BrNO
Molecular Weight:174

13472-85-0 Synthesis

13472-85-0
512 suppliers
$8.00/1g

13466-38-1
391 suppliers
$6.00/5g

Yield:13466-38-1 61.55%

Reaction Conditions:

with hydrogenchloride in water at 100; for 20 h;

Steps:

2.1 Step 1: Synthesis of Compound B-1_2
The mixture of 5-bromo-2-methoxypyridine (15.00 g, 79.78 mmol) and diluted hydrochloric acid (6M, 150 mE) was stirred for 20 hat 100° C. Afier the reaction finished, the mixture was diluted with water (600 mE), adjusted pH to 7 with aq. NaOH solution (iM), and then extracted with EtOAc (200 mE*4). The combined organic phase was washed with sat. aq NaC1 (20 mE), dried over Na2504, filtered and concentrated in vacuo. The residue was mashed with mixed solvents (PE/EtOAc =10/i, 100 mE), filtered and then washed with PE (5 mE*3), dried in vacuo to give compound B-i_2 as white solid (10.42 g, 61.55%). ‘H NMR (400 MHz, CDC13) ?: 11.76 (bts., iH), 7.70 (d, J=3.0 Hz, iH), 7.56 (dd, J=2.5, 9.5 Hz, iH), 6.36 (d, J=9.5 Hz, iH).

References:

SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.;SHIH, Neng-yang;CHEN, Bin;ZHANG, Lei;LI, Jian;CHEN, Shuhui US2019/62315, 2019, A1 Location in patent:Paragraph 0113; 0114

FullText

1072-97-5 Synthesis