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ChemicalBook CAS DataBase List 2-HYDROXY-4-BROMO-6-NITROTOLUENE
864550-41-4

2-HYDROXY-4-BROMO-6-NITROTOLUENE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 1 h / 20 °C
2.1: pyridine; diammonium sulfide / ethanol; water / 3 h / Reflux
3.1: sulfuric acid; sodium nitrite / water / 1 h / 0 °C
3.2: 130 °C

References:

Pandey, Sunil Kumar;Guttormsen, Yngve;Haug, Bengt Erik;Hedberg, Christian;Bayer, Annette [Organic Letters,2015,vol. 17,# 1,p. 122 - 125]