2-FLUORO-6-(TRIFLUOROMETHYL)BENZOIC ACID synthesis
- Product Name:2-FLUORO-6-(TRIFLUOROMETHYL)BENZOIC ACID
- CAS Number:32890-94-1
- Molecular formula:C8H4F4O2
- Molecular Weight:208.11
60611-24-7
201 suppliers
$10.00/1g
32890-94-1
142 suppliers
$12.00/1g
Yield: 88.4%
Reaction Conditions:
with potassium permanganate in water at 35 - 50; for 1 h;Large scale;Temperature;
Steps:
1-5 Synthesis of 2-fluoro-6-(trifluoromethyl)benzoic acid
Dissolve 5.13kg potassium permanganate in water and add it to the reaction kettle, then heat to 35°C, then add 4.8kg 2-fluoro-6-trifluoromethylbenzaldehyde dropwise to the reaction kettle, and control the reaction temperature to 5 After the sample was added dropwise, the reaction was kept at 50°C for 1 hour, and the reaction progress was monitored by HPLC.After the reaction is complete, add hydrochloric acid to adjust the pH to 1, then separate the layers, collect the organic layer, extract the aqueous layer twice with dichloromethane, combine the organic layers, and finally dry the organic layer with anhydrous sodium sulfate and concentrate under reduced pressure 4.6kg 2-fluoro-6-(trifluoromethyl)benzoic acid is obtained. After testing, the purity of 2-fluoro-6-(trifluoromethyl)benzoic acid prepared in Example 5 was greater than 99.0%, and the yield was 88.4%.
References:
CN112679374, 2021, A Location in patent:Paragraph 0037-0055
124-38-9
129 suppliers
$175.00/23402
401-80-9
307 suppliers
$5.00/10g
32890-94-1
142 suppliers
$12.00/1g