ChemicalBook CAS DataBase List 2-Fluoro-5-(trifluoromethyl)aniline

2-Fluoro-5-(trifluoromethyl)aniline synthesis

8synthesis methods

Product Name:2-Fluoro-5-(trifluoromethyl)aniline
CAS Number:535-52-4
Molecular formula:C7H5F4N
Molecular Weight:179.11

367-86-2 Synthesis

367-86-2
240 suppliers
$5.00/5g

7439-89-6
438 suppliers
$10.00/25g

535-52-4
261 suppliers
$5.00/1g

Yield:535-52-4 82%

Reaction Conditions:

with hydrogenchloride;sodium hydrogencarbonate in methanol;diethyl ether;

Steps:

R.1 Production of 2-fluoro-5-trifluoromethylaniline

Reference Example 1 Production of 2-fluoro-5-trifluoromethylaniline Twenty grams of 3-nitro-4-fluorobenzotrifluoride was dissolved in 50 ml of methanol. An iron powder (16 g) was added and concentrated hydrochloric acid was added dropwise with stirring. The reaction mixture was stirred overnight, followed by addition of sodium bicarbonate for neutralization. Then diethyl ether was added, and the insolubles were filtered off with cerite. The ether phase was separated, dried and concentrated under reduced pressure, giving 14 g of the contemplated product (yield 82%).

References:

EP1243584,2002,A1

367-86-2 Synthesis

367-86-2
240 suppliers
$5.00/5g

535-52-4
261 suppliers
$5.00/1g

References