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ChemicalBook CAS DataBase List 2-FLUORO-4-NITROBENZONITRILE
34667-88-4

2-FLUORO-4-NITROBENZONITRILE synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 52 percent / aq. CrO3; H2SO4; AcOH / 20 - 100 °C
2: (COCl)2; DMF / tetrahydrofuran / 3 h / 0 - 20 °C
3: 15.5 g / NH3 gas / tetrahydrofuran / 2.5 h / 0 °C
4: 14.7 g / Et3N; (CF3CO)2O / tetrahydrofuran / 16 h / 20 °C

References:

Mackman;Katz;Breitenbucher;Hui;Verner;Luong;Liu;Sprengeler [Journal of Medicinal Chemistry,2001,vol. 44,# 23,p. 3856 - 3871]

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