ChemicalBook CAS DataBase List 2-Fluoro-3-nitrobenzoic acid

2-Fluoro-3-nitrobenzoic acid synthesis

13synthesis methods

Product Name:2-Fluoro-3-nitrobenzoic acid
CAS Number:317-46-4
Molecular formula:C7H4FNO4
Molecular Weight:185.11

2-Fluoro-3-nitrobenzoic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research and development process. It was prepared from 2-fluoro-3-nitro-benzaldehyde, sodium chlorite and sulfamic acid by stirring in a 3:1 mixture of 1 ,4-dioxane/H2O for 30min at room temperature.

437-86-5 Synthesis

437-86-5
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$7.00/1g

317-46-4
292 suppliers
$6.00/1g

Yield:317-46-4 96%

Reaction Conditions:

with sodium dichromate in lithium hydroxide monohydrate;isopropanol at 25; for 3 h;Reagent/catalyst;Solvent;Temperature;

Steps:

3; 6; 9 Synthesis of 2-Fluoro-3-nitrobenzoic acid:

2-Fluoro-3-nitrotoluene (50.0g, 0.32mol) is dissolved in isopropanol (600mL) and water (300mL), sodium dichromate (150.0g, 0.57mol) is added, the reaction mixture is reacted at 25 °C for 3h, filtered, the filtrate is removed by steaming the organic solvent under reduced pressure, the residue is added to water stirring, heated and dissolved, reduced to 0 °C below recrystallization, to give 2-fluoro-3-nitrobenzoic acid (57.3g), yield 96%.

References:

CN114560774,2022,A Location in patent:Paragraph 0033-0035; 0042-0044; 0051-0053