ChemicalBook CAS DataBase List 2-(Diethylamino)acetamide

2-(Diethylamino)acetamide synthesis

3synthesis methods

Product Name:2-(Diethylamino)acetamide
CAS Number:7409-48-5
Molecular formula:C6H14N2O
Molecular Weight:130.19

683-57-8 Synthesis

683-57-8
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$6.00/1g

109-89-7
467 suppliers
$10.00/5g

7409-48-5
17 suppliers
$45.00/10mg

Yield:7409-48-5 79%

Reaction Conditions:

for 20 h;Reflux;

Steps:

1

2 g of 2-bromoacetannide (0.015 mol) were slowly added to diethylamine (40 ml_, 0.387 mol) and the reaction mixture was heated to reflux for 20 h. After cooling to room temperature, the reaction mixture was filtered and precipitate discarded. The filtrate was concentrated under vacuum to result in slightly yellow solid. This solid was dissolved in chloroform (10 ml_) and washed with aqueous saturated solution of Na2CO3 (3 x10 ml_). Combined organic phases were dried over Na2S0₄. The filtrate was concentrated under vacuum to result in 1 .49 g (79% yield) of light yellow solid, which was azeotropically dried with benzene prior to use in the following reactions. ¹ H NMR (500 MHz, CDCI₃, J = Hz): δ 6.19 (2H, s, br, NH₂), 3.01 (2H, s, CH₂), 2.56 (4H, q, J 7.2, NEt₂), 1 .04 (6H, t, J 7.3, NEt₂). ¹³C NMR (125.8 MHz, CDCI3): δ 175.6 (C=O), 57.4 (CH₂), 48.6, 12.3 (NEt₂). HRMS (ESIMS) m/z for C₆Hi₅N₂O [M+H]⁺ calcd 131 .1184, found 131 .0907.