ChemicalBook CAS DataBase List 2-CYANOETHYL PHOSPHORODICHLORIDITE

2-CYANOETHYL PHOSPHORODICHLORIDITE synthesis

5synthesis methods

Product Name:2-CYANOETHYL PHOSPHORODICHLORIDITE
CAS Number:76101-30-9
Molecular formula:C3H4Cl2NOP
Molecular Weight:171.95

42202-44-8
10 suppliers
inquiry

76101-30-9
41 suppliers
inquiry

Yield:-

Reaction Conditions:

with phosphorus trichloride in acetonitrile at 5;

Steps:

1 Example 1; Preparation and Stabilization of 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphoro-diamidite (PDA)

Example 1; Preparation and Stabilization of 2-Cyanoethyl- N, N, N', N'-tetraisopropylphosphoro-diamidite (PDA) 2- (cyanoethoxy) dichlororphosphine (CDP) can be easily prepared by various processes described in the prior art. For example, the reaction of phosphorous trichloride (PCl3) with either 2-cyanoethanol or trimethylsilyloxypropionitrile (TMSOP) gives CDP in good yield. If desired, the product can be purified with careful vacuum distillation. The CDP used in this example, and Example 2 was obtained by reacting PCI3 with TMSOP in a molar ratio of 2: 1 in acetonitrile at 5°C. Upon completion of the reaction, the solvent and the excess POS were removed by distillation. The crude product was further purified by vacuum distillation, and gave CDP with greater than 98% purity.

References:

WO2003/106468,2003,A1 Location in patent:Page 6-7

109-78-4 Synthesis