2-CYANO-N-CYCLOPROPYL-ACETAMIDE synthesis
- Product Name:2-CYANO-N-CYCLOPROPYL-ACETAMIDE
- CAS Number:15029-37-5
- Molecular formula:C6H8N2O
- Molecular Weight:124.14
Yield:15029-37-5 100%
Reaction Conditions:
at 45; for 1.5 h;
Steps:
2-Cyano-N-cyclopropylacetamide To a flask charged with cyclopropylamine (12.3 g, 215.3 mmol) was added ethyl cyanoacetate (9.8 g, 86.1 mmol). The reaction was stirred at 45° C. for 1.5 hour, cooled and concentrated under reduced pressure to give 10.7 g title compound (100%) as a light yellow solid. 1H NMR (300.132 MHz, CDCl3) δ 6.20 (bs, 1H), 3.34 (s, 2H), 2.75 (m, 2H), 0.83 (m, 2H), 0.59 (m, 2H).
References:
US2007/142328,2007,A1 Location in patent:Page/Page column 87
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