2-Chloro-6-hydroxynicotinic acid synthesis
- Product Name:2-Chloro-6-hydroxynicotinic acid
- CAS Number:38025-90-0
- Molecular formula:C6H4ClNO3
- Molecular Weight:173.55
38496-18-3
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38025-90-0
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$10.00/100mg
Yield: 88%
Reaction Conditions:
with water;sodium hydroxide at 129; for 4 h;
Steps:
1.a
Step a 2-chloro-6-oxo-1 ,6-dιhydropyrιdιne-3-carboxylιc acιd; ° A 500-mL round-bottom flask was charged with 2,6-dιchloronιcotιnιc acid (25 0 g 130 mmol), NaOH solution (325 ml_, 2N) and the solution was refluxed at 1290C for 4 hours The reaction mixture was cooled to room temperature and acidified with a 6N aq HCI solution The resulting precipitate was filtered and dried under reduced pressure yielding to the desired product (19 87g, 88%)
References:
Location in patent:Page/Page column 97
262423-77-8
201 suppliers
$9.00/1g
38025-90-0
131 suppliers
$10.00/100mg