ChemicalBook CAS DataBase List 2-CHLORO-5-HYDROXYBENZALDEHYDE

2-CHLORO-5-HYDROXYBENZALDEHYDE synthesis

6synthesis methods

Product Name:2-CHLORO-5-HYDROXYBENZALDEHYDE
CAS Number:7310-94-3
Molecular formula:C7H5ClO2
Molecular Weight:156.57

876299-47-7 Synthesis

876299-47-7
32 suppliers
inquiry

7310-94-3
77 suppliers
$21.00/250mg

Yield: 81%

Reaction Conditions:

with manganese(IV) oxide in acetone for 3 h;Heating / reflux;

Steps:

27 2-Chloro-5-hydroxy-benzaldehyde
Manganese dioxide (11 g, 125 mmol) was added to a suspension of the product of preparation 26 (4 g, 25.2 mmol) in acetone (25 mL) and the mixture was heated to reflux for 3 hours. The reaction mixture was then cooled to room temperature and concentrated in vacuo. The residue was dissolved in dichloromethane:methanol, 95:5, passed through a pad of silica and concentrated in vacuo to afford the title compound as a solid in 81% yield, 3.17 g

References:

Mathias, John Paul;Millan, David Simon;Lewthwaite, Russell Andrew;Phillips, Christopher US2006/35922, 2006, A1 Location in patent:Page/Page column 31