2-CHLORO-4'-METHOXYBENZOPHENONE synthesis

14synthesis methods

Product Name:2-CHLORO-4'-METHOXYBENZOPHENONE
CAS Number:54118-74-0
Molecular formula:C14H11ClO2
Molecular Weight:246.69

btained by reaction of 4-methoxybenzoyl chloride with chlorobenzene in the –presence of aluminium chloride in carbon disulfide at r.t. for 3 h (90%).

609-65-4 Synthesis

609-65-4
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$21.00/25g

100-66-3 Synthesis

100-66-3
523 suppliers
$10.00/5G

54118-74-0
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$23.00/1g

Yield:54118-74-0 98%

Reaction Conditions:

with copper(II) ferrite in 1,2-dichloro-ethane at 35 - 38; for 18 h;Friedel-Crafts Acylation;

Steps:

General procedure: The FC acylation of various benzenes with acid chlorides was carried out in the presence of magnetic nano CuFe2O4 (particle size = 50 nm) by using one of the reaction condition (A-D) given below. Condition A: Anisole/arene (1 mmol), acid chloride (1.2 mmol), nano CuFe2O4 (20 mol %), 1,2-DCE (2 mL), 80 C and 24 h. Condition B: Anisole/arene (1 mmol), acid chloride (1.2 mmol), nano CuFe2O4 (20 mol %), 1,2-DCE (2 mL), rt (35-38 C) and 18 h. Condition C: Neat reaction, anisole/arene (3.3 mmol), acid chloride (1.2 mmol), nano CuFe2O4 (20 mol %), rt (35-38 C) and 18 h. Condition D: Neat reaction, arene/anisole (3.3 mmol), acid chloride (1.2 mmol), nano CuFe2O4 (20 mol %), 80 C and 18 h.

References:

Parella, Ramarao;Naveen;Kumar, Amit;Babu, Srinivasarao Arulananda [Tetrahedron Letters,2013,vol. 54,# 13,p. 1738 - 1742] Location in patent:supporting information