(2-CHLORO-4-FLUOROPHENOXY)ACETIC ACID synthesis
- Product Name:(2-CHLORO-4-FLUOROPHENOXY)ACETIC ACID
- CAS Number:399-41-7
- Molecular formula:C8H6ClFO3
- Molecular Weight:204.58
1716-85-4
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399-41-7
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Yield:399-41-7 92.2%
Reaction Conditions:
with water;lithium hydroxide in methanol at 50; for 12 h;
Steps:
1
11.6 g of compound 2 was dissolved in 200 mL of methanol / water (10: 1), and 6.0 g of lithium hydroxide was added. The reaction system was heated to 50 ° C and stirred for 12h. The reaction was followed by TLC. After the reaction was completed, the reaction system was added to 500mL of ice water, and then adjusted to pH = 1 with 6mol / L HCl, and a large amount of white solid was formed. Filter, collect white solid, vacuum dry,9.4 g of white solid 3 was obtained. The yield was 92.2%.
References:
CN111072615,2020,A Location in patent:Paragraph 0020; 0022
1996-41-4
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399-41-7
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$60.00/100mg
405-79-8
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399-41-7
24 suppliers
$60.00/100mg
