2-CARBOXY-3-CARBOXYMETHYLQUINOLINE synthesis

2synthesis methods

Product Name:2-CARBOXY-3-CARBOXYMETHYLQUINOLINE
CAS Number:132623-44-0
Molecular formula:C12H9NO4
Molecular Weight:231.2

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Yield:-

Steps:

Multi-step reaction with 3 steps
1: 22 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 20 h / Heating
2: 66 percent / methanol / 1.) RT, 15 h, 2.) reflux, 2 h
3: 45 percent / 6 N aq. HCl / 4 h

References:

Gray, Nancy M.;Dappen, Michael S.;Cheng, Brian K.;Cordi, Alexis A.;Biesterfeldt, John P.;et al. [Journal of Medicinal Chemistry,1991,vol. 34,# 4,p. 1283 - 1292]

2-Quinolinecarboxylic acid, 3-(bromomethyl)-, methyl ester

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References