ChemicalBook CAS DataBase List 2-bromobutyrophenone

2-bromobutyrophenone synthesis

6synthesis methods

Product Name:2-bromobutyrophenone
CAS Number:877-35-0
Molecular formula:C10H11BrO
Molecular Weight:227.1

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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877-35-0
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$145.00/500mg

Yield: 167 mg

Reaction Conditions:

with water;sodium sulfite in ethyl acetate;acetone at 20;

Steps:

4.3. General procedure for synthesis of a-bromoketones (3a-3k)
General procedure: To a stirred solution of alkyne (1 mmol) in ethyl acetate(1 mL), 0.1 mL of acetone:water (1:1) and TsNBr2 (2 mmol) wasadded. After 10 min Na2SO3 (8 mmol) was added and the reaction was stirred at room temperature till completion asmonitored by TLC. The organic layer was extracted with ethylacetate, washed with water, dried with Na2SO4 and concentrated.The crude product was purified by flash chromatographyon silica gel (230-400 mesh) using petroleum ethereethyl acetateas eluent.

References:

Rajbongshi, Kamal Krishna;Hazarika, Debojit;Phukan, Prodeep [Tetrahedron,2016,vol. 72,# 29,p. 4151 - 4158]

495-40-9 Synthesis