2-BROMO-N,N-DIMETHYL-4-FLUOROANILINE synthesis
- Product Name:2-BROMO-N,N-DIMETHYL-4-FLUOROANILINE
- CAS Number:887268-19-1
- Molecular formula:C8H9BrFN
- Molecular Weight:218.07
130445-20-4
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887268-19-1
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Yield:887268-19-1 26%
Reaction Conditions:
Stage #1: 4-Fluoro-N,N-dimethylaniline N-oxidewith sulfurous dibromide in tetrahydrofuran at -78; for 4 h;Inert atmosphere;
Stage #2: with triethylamine in tetrahydrofuran at -78 - 23; for 0.75 h;Inert atmosphere;regioselective reaction;
References:
Reed, Hayley;Paul, Tyler R.;Chain, William J. [Journal of Organic Chemistry,2018,vol. 83,# 18,p. 11359 - 11368]