2-BROMO-6-HYDRAZINYLPYRIDINE synthesis
- Product Name:2-BROMO-6-HYDRAZINYLPYRIDINE
- CAS Number:26944-71-8
- Molecular formula:C5H6BrN3
- Molecular Weight:188.03
626-05-1
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$9.00/10g
26944-71-8
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$5.00/1g
Yield:26944-71-8 93%
Reaction Conditions:
with hydrazine hydrate in ethanol;water at 115; for 18 h;
Steps:
11.A
Commercially available 2,6-dibromopyridine (4.12 g, 16.6 mmol) was suspended in ethanol (40 mL) and hydrazine hydrate (10 mL, 97.6 mmol) in water (50-60%) was added. The mixture was heated in a sand-bath at 115° C. for 18 h. The solvent was removed and the residue was purified by chromatography on silica using ethyl acetate/n-heptane (60/40) to afford the title compound as an off-white solid (3.05 g, 93%).1H-NMR (400 MHz, CDCl3): =7.33 (t, 1H), 6.83 (d, 1H), 6.67 (d, 1H), 6.00 (br-s, 1H), 3.00-3.33 (br-s, 2H).
References:
AC Immune, S.A. US2011/256064, 2011, A1 Location in patent:Page/Page column 22
144100-07-2
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60-34-4
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$51.79/25g
26944-71-8
159 suppliers
$5.00/1g
144100-07-2
234 suppliers
$10.00/5g
26944-71-8
159 suppliers
$5.00/1g