ChemicalBook CAS DataBase List 2-Bromo-5-chloronitrobenzene

2-Bromo-5-chloronitrobenzene synthesis

7synthesis methods

Product Name:2-Bromo-5-chloronitrobenzene
CAS Number:41513-04-6
Molecular formula:C6H3BrClNO2
Molecular Weight:236.45

6280-88-2 Synthesis

6280-88-2
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$5.00/5g

41513-04-6
255 suppliers
$6.00/5g

Yield:41513-04-6 96%

Reaction Conditions:

with trichloroisocyanuric acid;bromine in tetrachloromethane at 10 - 100; for 18 h;Photolysis;

Steps:

4 Bromodecarboxylation of nitroarenecarboxylic acids

General procedure: A 25 mL round bottom flask equipped with Dimroth condenser (chilled to 10 °C) was charged with nitroarenecarboxylic acid ArC0₂H (1.8 mmol), chloroisocyanurate, brominating agent and solvent (8 mL). The mixture was stirred and heated in an oil bath under fluorescent room light irradiation (FL). The cooled reaction mixture was filtered through short silica gel pad, washed with 1 M aq Na₂S0₃, dried over Na₂S0₄, filtered and concentrated in vacuo to obtain bromonitroarene ArBr. The obtained product contained between 1-5% of the corresponding chloronitroarene ArCl as a by-product. The results are presented in Table 2. Table 2. Bromodecarboxylation of nitroarenecarboxylic acids ArC0₂H ^a

References:

WO2017/60906,2017,A1 Location in patent:Paragraph 00122

89-63-4 Synthesis