2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID synthesis
- Product Name:2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
- CAS Number:40003-41-6
- Molecular formula:C5H4BrNO2S
- Molecular Weight:222.06
67899-00-7
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40003-41-6
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$9.00/1g
Yield: 63%
Reaction Conditions:
with tert.-butylnitrite;copper(I) bromide in acetonitrile for 2 h;Heating / reflux;
Steps:
98.4
Step 4: 2-Bromo-4-methylthiazole-5-carboxylic acid Copper (I) bromide (2.1 g, 14.62 mmol) and t-BuONO (6.5 g, 62.97 mmol) were added to a solution of 2-amino-4-methylthiazole-5-carboxylic acid (2 g, 11.38 mmol) in ACN (60 mL). The resulting solution was stirred for 2 h at reflux. The mixture was poured into water (100 mL) and extracted with EtOAc (3*100 mL). The organics were combined, dried over Na2SO4, and evaporated to afford 2 g (63%) of 2-bromo-4-methylthiazole-5-carboxylic acid as a yellow solid.
References:
KALYPSYS, INC. US2008/139558, 2008, A1 Location in patent:Page/Page column 51
22900-83-0
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40003-41-6
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$9.00/1g
7210-76-6
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$5.00/1g
40003-41-6
129 suppliers
$9.00/1g