ChemicalBook CAS DataBase List 2'-BROMO-4'-CHLOROACETANILIDE

2'-BROMO-4'-CHLOROACETANILIDE synthesis

12synthesis methods

Product Name:2'-BROMO-4'-CHLOROACETANILIDE
CAS Number:57045-85-9
Molecular formula:C8H7BrClNO
Molecular Weight:248.5

873-38-1 Synthesis

873-38-1
285 suppliers
$6.00/5g

108-24-7
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$14.00/250ML

57045-85-9
42 suppliers
$46.00/1g

Yield:57045-85-9 99%

Reaction Conditions:

with dmap in chloroform; for 6 h;Reflux;

Steps:

N-Acetylation; General Procedure

General procedure: In a 50-mL, round-bottom flask, aniline (5.0 mmol, 1.0 equiv) was dissolved in CHCl3 (20 mL), followed by addition of DMAP (0.031 g, 0.25 mmol, 5 mol%). Ac2O (0.51 g, 5.0 mmol, 1.0 equiv) was added dropwise, and the mixture was stirred at reflux temperature (TLC monitoring) until completion. The mixture was cooled to r.t. and washed with distilled water. The organic layer was dried (anhyd MgSO4), followed by removal of solvent under reduced pressure to obtain the crude product, which was purified by flash chromatography (EtOAc/n-hexane).

References:

Baek, Junghyun;Ban, Jaeyoung;Lim, Minkyung;Rhee, Hakjune;Shabbir, Saira [Synthesis,2020,vol. 52,# 6,p. 917 - 927]