ChemicalBook CAS DataBase List 2-Bromo-3-nitrotoluene

2-Bromo-3-nitrotoluene synthesis

9synthesis methods

Product Name:2-Bromo-3-nitrotoluene
CAS Number:41085-43-2
Molecular formula:C7H6BrNO2
Molecular Weight:216.03

13506-76-8
253 suppliers
$6.00/1g

41085-43-2
193 suppliers
$6.00/1g

Yield: 30%

Reaction Conditions:

with 2.9-dimethyl-1,10-phenanthroline;oxygen;copper (I) acetate;silver sulfate;sodium bromide in dimethyl sulfoxide at 160; for 24 h;Schlenk technique;

Steps:

24 Example 24. Synthesis of 2-nitro-6-methyl bromobenzene.
Silak reaction tube equipped with a magnetic stirrer was charged with 6.2 mg of silver sulfate,36.3 mg of copper acetate, 12.5 mg of 2,9-dimethyl-1,10-o-phenanthroline,36.2 mg of 2-nitro-6-methylbenzoic acid and 30.9 mg of sodium bromide4 mL of dimethyl sulfoxide.The reaction was heated at 160 ° C for 24 hours in the presence of oxygen.After the reaction was completed, distilled water was added to quench the reaction,Extraction with ethyl acetate 3 times, each time 10mL,The combined organic phases are concentrated,13.0 mg of 2-nitro-6-methylbromobenzene was obtained in a yield of 30%.

References:

Nanchang University;Fu Zhengjiang;Cai Hu;Li Zhaojie;Jiang Ligao CN107325002, 2017, A Location in patent:Paragraph 0118

570-24-1 Synthesis