2-Bromo-3-fluorobenzoyl chloride synthesis
- Product Name:2-Bromo-3-fluorobenzoyl chloride
- CAS Number:1000339-91-2
- Molecular formula:C7H3BrClFO
- Molecular Weight:237.45
132715-69-6
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1000339-91-2
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Yield:1000339-91-2 81%
Reaction Conditions:
with thionyl chloride at 100;
Steps:
1.1. Chlorination of bromo-fluoro-substituted-benzoic acids
General procedure: To 2-bromo-5-fluorobenzoic acid 8p (500 mg, 2.28 mmol) was added thionyl chloride (207 μL, 2.85 mmol). The mixture was heated for 1.5 h at 100 °C (an additional 1 mL of SOCl2 was added after 20 min). The thionyl chloride was evaporated and the product, 1.1.1. 2-bromo-5-fluorobenzoyl chloride (2p), was used without further purification.
References:
Yu, Zhiyi;Van Veldhoven, Jacobus P.D.;'T Hart, Ingrid M.E.;Kopf, Adrian H.;Heitman, Laura H.;Ijzerman, Adriaan P. [European Journal of Medicinal Chemistry,2015,vol. 106,p. 50 - 59] Location in patent:supporting information
317-20-4
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348-54-9
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349-24-6
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1000339-91-2
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825-22-9
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1000339-91-2
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