ChemicalBook CAS DataBase List 2-Bromo-3-fluoroaniline

2-Bromo-3-fluoroaniline synthesis

14synthesis methods

Product Name:2-Bromo-3-fluoroaniline
CAS Number:111721-75-6
Molecular formula:C6H5BrFN
Molecular Weight:190.01

59255-94-6
137 suppliers
$19.00/1g

111721-75-6
174 suppliers
$27.60/250mg

Yield:111721-75-6 98%

Reaction Conditions:

with hydrogen;nickel in methanol at 20; under 7500.75 Torr; for 5 h;Autoclave;Solvent;Pressure;

Steps:

1.2 2. Preparation of 1-fluoro-2-bromo-3-aminobenzene
22.0 g of 1-fluoro-2-bromo-3-nitrobenzene was added to a 500 mL stainless steel autoclave.220.0 g of methanol and 2.2 g of Raney nickel catalyst. Stir vigorously for 5 hours at room temperature and 1 MPa hydrogen pressure.The catalyst was filtered off, and the mother liquid was concentrated to give a solvent to give 1-fluoro-2-bromo-3-aminobenzene (18.6 g, yield 98%).

References:

Jinkai (Liaoning) Chemical Co., Ltd.;Li Zhenwei;Zhao Yang;Li Degang;Liu Shukuan;Jiang Zhipeng;Liu Haisheng;Wang Dong;Zhao Hongyang;Song Tongji CN108002976, 2018, A Location in patent:Paragraph 0045; 0047; 0050; 0051; 0060; 0069

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