2-Bromo-2'-chloroacetophenone synthesis
- Product Name:2-Bromo-2'-chloroacetophenone
- CAS Number:5000-66-8
- Molecular formula:C8H6BrClO
- Molecular Weight:233.49
2142-68-9
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Yield:5000-66-8 99%
Reaction Conditions:
with bromine in water at 20; for 0.75 h;Large scale;
Steps:
1.1 (1) Synthesis of α-bromo-2-chloroacetophenone (3)
Add 230.0g (1.5mol) o-chloroacetophenone and 1188mL water into a 3L three-necked flask, react at 20°C, add 84.4mL (1.6mol) liquid bromine dropwise within 0.5h, and stir for 15min. It was extracted with 400 mL of dichloromethane, and the organic layer was washed with 4.7 mol/L sodium carbonate aqueous solution and dried with anhydrous sodium sulfate. After filtering and evaporating the solvent under reduced pressure, 346.3 g of pale yellow oily liquid was obtained with a yield of 99%.
References:
CN112707829, 2021, A Location in patent:Paragraph 0036-0038
1056775-36-0
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5000-66-8
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