ChemicalBook CAS DataBase List 2-bromo-1-methoxy-4-phenyl-benzene

2-bromo-1-methoxy-4-phenyl-benzene synthesis

5synthesis methods

Product Name:2-bromo-1-methoxy-4-phenyl-benzene
CAS Number:74447-73-7
Molecular formula:C13H11BrO
Molecular Weight:263.13

613-37-6 Synthesis

613-37-6
121 suppliers
$25.00/5g

74447-73-7
36 suppliers
$45.00/50mg

Yield:74447-73-7 98 %

Reaction Conditions:

with dibromohydantoin in dichloromethane at 0;Reagent/catalyst;

Steps:

1-4 embodiment 2 The preparation of compound II

Add compound I (36.8g) into the reaction flask, then add dichloromethane (200mL), slowly add dibromohydantoin (68.6g) at 0°C, continue the reaction for 3h, the content of raw materials detected by HPLC is less than 1%, filter , the mother liquor was concentrated to remove dichloromethane, and the residue was crystallized with methanol, filtered and dried to obtain compound II, 51.6g, yield 98%, HPLC purity 99.9%.

References:

CN115417797,2022,A Location in patent:Paragraph 0043-0051

768-32-1 Synthesis