ChemicalBook CAS DataBase List 2-bromo-1-(4-bromo-3-fluorophenyl)ethanone

2-bromo-1-(4-bromo-3-fluorophenyl)ethanone synthesis

4synthesis methods

Product Name:2-bromo-1-(4-bromo-3-fluorophenyl)ethanone
CAS Number:1003879-02-4
Molecular formula:C8H5Br2FO
Molecular Weight:295.93

304445-49-6 Synthesis

304445-49-6
125 suppliers
$8.00/100mg

2-bromo-1-(4-bromo-3-fluorophenyl)ethanone

1003879-02-4
36 suppliers
$138.00/250mg

Yield:1003879-02-4 44%

Reaction Conditions:

with copper(ll) bromide in ethyl acetate at 60; for 12 h;

Steps:

18a Step 18a.
A mixture of 1-(4-bromo-3-fluorophenyl)ethanone (1 g, 4.6 mmol), copper(II) bromide (2.1 g, 9.7 mmol) in EtOAc (50 mL) was stirred for 12 hours at 60° C. The mixture was allowed to cool down and filtered. The filtrate was concentrated. The residue was chromatographed (silica, ethyl acetate/petroleum ether) to give the desired compound as a yellow solid (600 mg, 44%).

References:

ENANTA PHARMACEUTICALS, INC.;Qiu, Yao-Ling;Cao, Hui;Li, Wei;Kass, Jorden;Gao, Xuri;Peng, Xiaowen;Jin, Meizhong;Or, Yat Sun US2016/289212, 2016, A1 Location in patent:Paragraph 0270

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