2-(Aminomethyl)quinoline-8-ol synthesis
- Product Name:2-(Aminomethyl)quinoline-8-ol
- CAS Number:17018-81-4
- Molecular formula:C10H10N2O
- Molecular Weight:174.2
5603-22-5
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Yield:17018-81-4 82%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol at 20; for 4 h;
Steps:
4 Example [4-2-AMINOMETHYL-QUINOLIN-8-OL] E1 (Scheme 4)
8-Hydroxy-quinoline-2-carboxaldehyde oxime [DL] (167 mg, 0. [888] mmol) and [MEOH] (50 mL) was treated under hydrogenolysis conditions (atmospheric H2, catalytic 10% Pd/carbon) at RT. After 4 h, the catalyst was filtered off and the volatiles removed which afforded 2-aminomethyl- quinolin-8-ol El as a light brown solid (126 mg, 82%); spectral data of this compound are given in Table 2.
References:
WO2004/7461,2004,A1 Location in patent:Page 39
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17018-81-4
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17018-82-5
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