ChemicalBook CAS DataBase List 2-AMINO-5-FLUOROBENZENETHIOL

2-AMINO-5-FLUOROBENZENETHIOL synthesis

9synthesis methods

Product Name:2-AMINO-5-FLUOROBENZENETHIOL
CAS Number:33264-82-3
Molecular formula:C6H6FNS
Molecular Weight:143.18

399-73-5 Synthesis

Benzothiazole, 6-fluoro-2-methyl- (7CI,8CI,9CI)

399-73-5
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$51.00/250mg

33264-82-3
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$45.00/25mg

Yield:33264-82-3 96%

Reaction Conditions:

with water;sodium hydroxide in ethylene glycol at 140; for 6 h;

Steps:

89.1 Step 1: 2-Amino-S -fluorobenzenethiol (2):

To a solution of 6-fluoro-2-methylbenzo[djthiazole 1 (2 g, 11.96 mmol) in ethylene glycol (10 mL) was added 8 N NaOH (8 mL). The resulting reaction mixture was stirred at 140°C for 6 h. Progress of the reaction was monitored by TLC. After completion, the reaction mixture was cooled to room temperature; acidified with iN HC1 up to pH=6 and extracted with ethyl acetate. The combined organic layer was dried over anhydrous Na2SO4 filtered and concentrated under reduced pressure to afford the title compound 2 as yellow solid (1.65 g, yield96%).

References:

WO2016/197078,2016,A1 Location in patent:Paragraph 822-823

348-40-3 Synthesis