2-Amino-5-diethylaminopentane synthesis
- Product Name:2-Amino-5-diethylaminopentane
- CAS Number:140-80-7
- Molecular formula:C9H22N2
- Molecular Weight:158.28
67459-50-1
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140-80-7
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Yield:140-80-7 97.2%
Reaction Conditions:
with nickel in toluene at 70; for 12 h;
Steps:
7 Racemization of (R)-2-amino-5-diethylaminopentane
Weigh 36g (0.23mol) of R-hydroxychloroquine side chain (chemical name: (R)-2-amino-5-diethylaminopentane), dissolve it in 250mL of toluene, add 1.8g of Raleigh nickel, Under normal pressure and hydrogen atmosphere, the reaction was stirred at 70°C for 12 hours. When the optical rotation of the reaction supernatant was measured to be zero or close to zero, the reaction supernatant was cooled, allowed to stand, and filtered with suction. The filtrate was concentrated to dryness to obtain a colorless oily liquid 35.2 G, it is (±)-2-amino-5-diethylaminopentane, the yield is 97.2%.
References:
South University of Science and Technology of China;Sun Yat-sen University;Zhang Xumu;Luo Haibin;Zhang Yantao;Li Yingjun;Li Guanguan;Shi Yongjie;Huang Yiyou;Li Zhe;Zou Yong;Chen Xinzi CN111803501, 2020, A Location in patent:Paragraph 0120; 0123-0124
105-14-6
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140-80-7
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$48.00/25mL
5412-69-1
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140-80-7
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140-80-7
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140-80-7
174 suppliers
$48.00/25mL