ChemicalBook CAS DataBase List 2-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID

2-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID synthesis

8synthesis methods

Product Name:2-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID
CAS Number:402-13-1
Molecular formula:C8H6F3NO2
Molecular Weight:205.13

320-94-5
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402-13-1
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$18.00/5g

Yield:402-13-1 100%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol at 20; under 5250.53 Torr; for 2 h;

Steps:

1
Example 1 :; N-(6-Acetyl-2,4-dioxo-7-trifluoromethyl-l,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide; 2-Amino-4-trifluoromethyl-benzoic acid; A solution of 2-nitro-4-trifluoromethyl-benzoic acid (100 g, 425 mmol) in MeOH (600 mL) was treated with palladium on carbon (10%) and the mixture was stirred at r.t. for 2 h under hydrogen (7 bars). The mixture was then filtered and concentrated in vacuo to give 2-amino-4-trifluoromethyl-benzoic acid (87.2 g, 425 mmol, 100%) as a yellow solid, m.p. 172-173 ⁰C, ESI-MS: m/z 206 [M+H]⁺.

References:

NOVARTIS AG;NOVARTIS PHARMA GMBH WO2006/108591, 2006, A1 Location in patent:Page/Page column 10; 66

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