ChemicalBook CAS DataBase List 2-AMINO-4-NITROPYRIDINE-N-OXIDE

2-AMINO-4-NITROPYRIDINE-N-OXIDE synthesis

5synthesis methods

Product Name:2-AMINO-4-NITROPYRIDINE-N-OXIDE
CAS Number:52092-45-2
Molecular formula:C5H5N3O3
Molecular Weight:155.11

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Yield:52092-45-2 90.3%

Reaction Conditions:

with sulfuric acid;nitric acid at 10 - 90; for 5 h;

Steps:

2 Preparation of 2-amino-4-nitropyridine N-oxide

Concentrated sulfuric acid (210mL) was added to the 1L four-neck flask.The ice bath is cold below 10°C.Batch adding the product as above,Stirring,The mixed acid composed of fuming nitric acid (300 mL) and concentrated sulfuric acid (150 mL) was slowly added dropwise.After dripping to 90°C for 5 hours,Cold to 5 ~ 10 °C,Pour into ice water (700 mL) with stirring.Adjust to pH=6 with 30% ammonia water,filter,The filter cake is dried at 80°C.Obtained white solid compound b (140 g, 90.3%),98% purity.

References:

CN107759515,2018,A Location in patent:Paragraph 0029-0031