ChemicalBook CAS DataBase List 2-Amino-2,3-dimethylbutyronitrile

2-Amino-2,3-dimethylbutyronitrile synthesis

5synthesis methods

Product Name:2-Amino-2,3-dimethylbutyronitrile
CAS Number:13893-53-3
Molecular formula:C6H12N2
Molecular Weight:112.17

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Yield:-

Reaction Conditions:

with ammonia in water

Steps:

3 Resolution of racemic 2-amino-2,3-dimethylbutyronitrile
EXAMPLE 3 Resolution of racemic 2-amino-2,3-dimethylbutyronitrile To an ice-cold solution of 80 g (+)-tartaric acid in 200 ml water is added 56 g of -2-amino-2,3-dimethylbutyronitrile. During the addition, the mixture is kept cold. The precipitate is collected by filtration, washed with a small amount of ice-cold water and air dried to yield 65.25 g tartrate salt "B". The filtrate from "B" is treated with 56 ml of concentrated ammonia and extracted 3 times with ether, the combined extracts are washed with brine, dried and concentrated to yield 24.0 g of (-)-2-amino-2,3-dimethylbutyronitrile "A", [α]_D²⁵ =-4.49° (c=0.0376 g/ml THF).

References:

American Cyanamid Company US4683324, 1987, A

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