Yield: 65%

Reaction Conditions:

with iodine;sodium hydroxide in water at 80; for 2 h;

Steps:

62.1.A
Step A:
2,6-Dimethylpyrimidin-4-ol (5.0 g, 40 mmol) was dissolved in aqueous NaOH solution (50 mL, 1 M, 50 mmol).
To the solution was added iodine (10.2 g, 40 mmol).
The mixture was gradually heated to 80° C. and stirred for 2 h.
After cooling the mixture to room temperature, acetic acid was added to adjust the pH ?6.
A precipitate formed and was collected by filtration.
The solid was washed with water and dried to give 5-iodo-2,6-dimethylpyrimidin-4-ol (6.51 g, 65%). MS m/z 251.2 [M+H]⁺.

References:

PTC Therapeutics, Inc.;F. Hoffmann-La Roche AG;Woll, Matthew G.;Chen, Guangming;Choi, Soongyu;Dakka, Amal;Huang, Song;Karp, Gary Mitchell;Lee, Chang-Sun;Li, Chunshi;Narasimhan, Jana;Naryshkin, Nikolai;Paushkin, Sergey;Qi, Hongyan;Turpoff, Anthony A.;Weetall, Marla L.;Welch, Ellen;Yang, Tianle;Zhang, Nanjing;Zhang, Xiaoyan;Zhao, Xin;Pinard, Emmanuel;Ratni, Hasane US9617268, 2017, B2 Location in patent:Page/Page column 398