ChemicalBook CAS DataBase List 2,6-DIFLUORO-4-METHOXYBENZYL BROMIDE

2,6-DIFLUORO-4-METHOXYBENZYL BROMIDE synthesis

4synthesis methods

Product Name:2,6-DIFLUORO-4-METHOXYBENZYL BROMIDE
CAS Number:94278-68-9
Molecular formula:C8H7BrF2O
Molecular Weight:237.04

79538-27-5 Synthesis

79538-27-5
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$150.00/5G

94278-68-9
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$67.50/250mg

Yield:94278-68-9 66%

Reaction Conditions:

with phosphorus(V) oxybromide in tetrahydrofuran at 20; for 2 h;

Steps:

56.3 Step3:

Step3: To a cold stirring solution of (2,6-difluoro-4-methoxyphenyl)MeOH (0.5 g, 2.87 mmol, 1 eq) in THF (20 ml) was portion wise added ROB_{FontWeight="Bold" FontSize="10"} (1.65 g, 5.74 mmol, 2 eq). The reaction mixture then stirred for 2 h at RT. The reaction mixture was quenched by saturated NaHCCb solution under cooling conditions. The organic layer was separated and aqueous layer was extracted by EtOAc (50 ml). The combined organic layer was washed by water (30 ml) and brine (30 ml). [71] The organic layer was dried over anhydrous Na₂SC>₄, concentrated under reduced pressure to get the crude material which was purified by silica gel (230-400 mesh silica gel; 10% EtO Ac/hexane; R value-0.5) to afford 2-(bromomethyl)-1,3-difluoro-5-methoxybenzene (0.45 g, 66%) as color less liquid.

References:

WO2019/170904,2019,A1 Location in patent:Page/Page column 69-73

79538-28-6 Synthesis